This is a brief report to provide a summary of results from the post-covid-events analyses performed in OpenSAFELY. Cohorts = Pre-Vaccination Outcome = Diabetes (Type-2, Type-1, Unspecified). PLEASE NOTE that these results are preliminary and subject to change.
Data downloaded as CSV from here
N.B.includes B, Alpha, Delta and Omicron variants. Data additionally
downloaded from here
for pre-September-2020 case estimates before variant monitoring was
present.
| Covariate | Covariate Level | Prevax Population | Prevax Number diagnosed with COVID 19 risk per 100 000 | Vax Population | Vax Number diagnosed with COVID 19 risk per 100 000 | Unvax Population | Unvax Number diagnosed with COVID 19 risk per 100 000 |
|---|---|---|---|---|---|---|---|
| All | All | 15175714 | 826582 (5447) | 11789177 | 749030 (6354) | 2859217 | 147221 (5149) |
| sex | Female | 7661354 | 450927 (5886) | 6215420 | 422129 (6792) | 1175305 | 78623 (6690) |
| sex | Male | 7514360 | 375655 (4999) | 5573757 | 326901 (5865) | 1683912 | 68598 (4074) |
| ethnicity | White | 11903511 | 620076 (5209) | 9707785 | 638738 (6580) | 1779237 | 112236 (6308) |
| ethnicity | Mixed | 172865 | 11633 (6730) | 106623 | 6461 (6060) | 69993 | 3656 (5223) |
| ethnicity | South Asian | 898418 | 91607 (10196) | 602213 | 31935 (5303) | 275991 | 9083 (3291) |
| ethnicity | Black | 310993 | 21368 (6871) | 172488 | 7751 (4494) | 147557 | 7089 (4804) |
| ethnicity | Other | 324162 | 16366 (5049) | 197166 | 9022 (4576) | 160219 | 3869 (2415) |
| ethnicity | Missing | 1565765 | 65532 (4185) | 1002902 | 55123 (5496) | 426220 | 11288 (2648) |
| deprivation | 1-2 (most deprived) | 2884715 | 199770 (6925) | 1855885 | 112614 (6068) | 853767 | 44237 (5181) |
| deprivation | 4-Mar | 2979353 | 178027 (5975) | 2178752 | 135956 (6240) | 686486 | 34821 (5072) |
| deprivation | 6-May | 3270564 | 165138 (5049) | 2608923 | 161359 (6185) | 572151 | 29274 (5116) |
| deprivation | 8-Jul | 3125930 | 151191 (4837) | 2608726 | 168320 (6452) | 436022 | 22481 (5156) |
| deprivation | 9-10 (least deprived) | 2915152 | 132456 (4544) | 2536891 | 170781 (6732) | 310791 | 16408 (5279) |
| region | East | 3573633 | 190145 (5321) | 2803397 | 161606 (5765) | 651907 | 34026 (5219) |
| region | East Midlands | 2660822 | 157083 (5904) | 2062410 | 138181 (6700) | 469981 | 28224 (6005) |
| region | London | 953066 | 52592 (5518) | 601019 | 31973 (5320) | 402794 | 10645 (2643) |
| region | North East | 745041 | 50517 (6780) | 570462 | 43106 (7556) | 123655 | 7181 (5807) |
| region | North West | 1351813 | 89454 (6617) | 1061351 | 75200 (7085) | 194470 | 11823 (6080) |
| region | South East | 1012424 | 41114 (4061) | 826297 | 50120 (6066) | 172818 | 8829 (5109) |
| region | South West | 2137597 | 63752 (2982) | 1838482 | 113835 (6192) | 286399 | 17461 (6097) |
| region | West Midlands | 576450 | 42844 (7432) | 399351 | 24838 (6220) | 148932 | 7454 (5005) |
| region | Yorkshire and The Humber | 2164868 | 139081 (6424) | 1626408 | 110171 (6774) | 408261 | 21578 (5285) |
| smoking status | Never smoker | 7088744 | 422829 (5965) | 5619699 | 371342 (6608) | 1178313 | 59118 (5017) |
| smoking status | Ever smoker | 4781706 | 250809 (5245) | 4107299 | 280313 (6825) | 560552 | 42410 (7566) |
| smoking status | Current smoker | 2650985 | 115959 (4374) | 1668733 | 82264 (4930) | 785342 | 37154 (4731) |
| smoking status | Missing | 654279 | 36985 (5653) | 393446 | 15111 (3841) | 335010 | 8539 (2549) |
| bmi groups | Missing | 2477686 | 147710 (5962) | 1498710 | 75454 (5035) | 895225 | 32732 (3656) |
| bmi groups | Healthy_weight | 4806928 | 231382 (4814) | 3730127 | 229980 (6165) | 931142 | 46758 (5022) |
| bmi groups | Underweight | 283648 | 13039 (4597) | 203769 | 9397 (4612) | 80957 | 3419 (4223) |
| bmi groups | Overweight | 4451907 | 234464 (5267) | 3680896 | 239204 (6499) | 587603 | 35693 (6074) |
| bmi groups | Obese | 3155545 | 199987 (6338) | 2675675 | 194995 (7288) | 364290 | 28619 (7856) |
| age group | 18-29 | 2766105 | 216349 (7821) | 1572826 | 84052 (5344) | 881360 | 40039 (4543) |
| age group | 30-39 | 2813879 | 183955 (6537) | 1772688 | 134877 (7609) | 876730 | 51058 (5824) |
| age group | 40-49 | 2682572 | 168528 (6282) | 1979944 | 214431 (10830) | 550325 | 33775 (6137) |
| age group | 50-59 | 2755651 | 154407 (5603) | 2344031 | 179121 (7642) | 321822 | 16044 (4985) |
| age group | 60-69 | 1996255 | 66053 (3309) | 1867109 | 85034 (4554) | 145286 | 4621 (3181) |
| age group | 70-79 | 1492285 | 25991 (1742) | 1512358 | 39359 (2602) | 59091 | 1206 (2041) |
| age group | 80-89 | 585198 | 8852 (1513) | 627148 | 10279 (1639) | 19754 | 405 (2050) |
| age group | 90+ | 83769 | 2447 (2921) | 113073 | 1877 (1660) | 4849 | 73 (1505) |
| consulation rate group | 0 | 4251535 | 188009 (4422) | 2926673 | 170113 (5813) | 1550844 | 45547 (2937) |
| consulation rate group | 1 to 6 | 5957458 | 347783 (5838) | 4812285 | 320995 (6670) | 804368 | 57319 (7126) |
| consulation rate group | 6+ | 4966721 | 290790 (5855) | 4050219 | 257922 (6368) | 504005 | 44355 (8801) |
| consulation rate | Mean | 5 | 6 (107972) | 6 | 5 (99565) | 3 | 5 (167146) |
| tc hdl ratio | Mean | 4 | 4 (95000) | 4 | 4 (92500) | 4 | 4 (99211) |
| History of all stroke | TRUE | 176279 | 6243 (3542) | 184967 | 6463 (3494) | 10048 | 548 (5454) |
| History of ami | TRUE | 248660 | 8571 (3447) | 252988 | 9412 (3720) | 12901 | 684 (5302) |
| History of angina | TRUE | 384477 | 12426 (3232) | 381653 | 13802 (3616) | 15388 | 810 (5264) |
| History of cancer | TRUE | 4581503 | 282844 (6174) | 4091955 | 321575 (7859) | 542092 | 50801 (9371) |
| History of carehome status | TRUE | 25655 | 3972 (15482) | 29267 | 1378 (4708) | 2000 | 70 (3500) |
| History of chronic kidney disease | TRUE | 637649 | 21221 (3328) | 654909 | 22271 (3401) | 30240 | 1777 (5876) |
| History of chronic obstructive pulmonary disease | TRUE | 374624 | 12697 (3389) | 368930 | 13582 (3681) | 20837 | 1001 (4804) |
| History of dementia | TRUE | 81044 | 5399 (6662) | 94867 | 2915 (3073) | 3017 | 154 (5104) |
| History of depression | TRUE | 4212896 | 239556 (5686) | 3494127 | 239874 (6865) | 631362 | 47049 (7452) |
| History of diabetes gestational | TRUE | 82980 | 6448 (7771) | 75904 | 8444 (11125) | 22478 | 2561 (11393) |
| History of healthcare worker | TRUE | 480633 | 55407 (11528) | 414767 | 33701 (8125) | 17582 | 2084 (11853) |
| History of hf | TRUE | 180577 | 6366 (3525) | 204741 | 7166 (3500) | 8572 | 476 (5553) |
| History of hypertension | TRUE | 4358003 | 201059 (4614) | 4e+06 | 212405 (5311) | 372096 | 27135 (7292) |
| History of liver disease | TRUE | 85527 | 3951 (4620) | 78270 | 3746 (4786) | 12788 | 651 (5091) |
| History of other arterial embolism | TRUE | 68884 | 2692 (3908) | 83968 | 3513 (4184) | 4914 | 281 (5718) |
| History of prediabetes | TRUE | 731601 | 30118 (4117) | 821101 | 35836 (4364) | 52224 | 3352 (6419) |
| History of vte | TRUE | 216641 | 9425 (4351) | 214363 | 11133 (5194) | 21533 | 1662 (7718) |
To be completed.
N.B. There were too few events for Other or Non-Specific Diabetes in the Unvaccinated Cohort.
N.B. Results not shown for any subgroup with too few events according to criteria set out in the pre-specified analysis plan
N.B. Full time point results were not ran in the unvaccinated cohort due to the number of events.
| Measure | Prevaccinated | Vaccinated | Unvaccinated |
|---|---|---|---|
| Duration (days) | 535 | 197 | 197 |
| Sample Size | 15176232 | 12752330 | 3095271 |
| Type 2 Diabetes cases during study period (N) | 184800 | 83902 | 6839 |
| Type 2 Diabetes cases during study period (%) | 1.22 | 0.66 | 0.22 |
| Averaged number of Type 2 Diabetes diagnoses per day | 345 | 425 | 35 |